- Sega Bass Fishing 2 – USA
- Sega GT – USA
- Sega GT – PAL
- Sega Marine Fishing – USA
- Sega Rally 2 – USA
- Sega Rally 2 – PAL
- Sega Smashpack Volume 1 – USA
- Sega Worldwide Soccer 2000 – PAL
- Seventh Cross Evolution – USA
- Shadow Man – USA
- Shadow Man Ver. 1.1 – USA
- Shadowman – PAL
- Shenmue – USA
- Shenmue – PAL
- Shenmue (Import) – JAP
- Shinseiki Evangelion – JAP
- Shutokou Battle 2 (Import) – JAP
- Silent Scope – USA
- Silent Scope – PAL
- Silver – USA
- Silver – PAL
- Skies of Arcadia – USA
- Skies of Arcadia – PAL
- Slave Zero – USA
- Slave Zero – PAL
- Sno Cross Championship Racing – USA
- SnoCross Championship Racing – PAL
- Snow Surfers – PAL
- Soldier Of Fortune – USA
- Soldier Of Fortune – PAL
- Sonic Adventure – USA
- Sonic Adventure (Import) – JAP
- Sonic Adventure v1.1 – USA
- Sonic Adventures – PAL
- Sonic Shuffle – USA
- Sonic Shuffle – PAL
- Soul Calibur – USA
- Soul Calibur – PAL
- Soul Fighter – USA
- Soul Fighter – PAL
- Soul Reaver – PAL
- South Park Chef’s Luv Shack – USA
- South Park Rally – USA
- South Park Rally – PAL
- Space Channel 5 – USA
- Spawn – USA
- Spawn In The Demons Hand – PAL
- Spec Ops: Omega Squad – USA
- Speed Devils – USA
- Speed Devils – PAL
